Evidence map›Paper›PMID 42158763›Full record

ArticleCureus2026

Medication Abortion Failure in a Patient With Class III Obesity and Twin Gestation: A Case Report.

Dan Schaefer, Aaron Brown, Melissa A Adler, J Bradley Stern

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dan SchaeferDepartment of Family Medicine, University of Colorado Health, Fort Collins, USA.
Aaron BrownDepartment of Pharmacology, University of Wyoming, Laramie, USA.
Melissa A AdlerDepartment of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, USA.
J Bradley SternDepartment of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a paucity of clinical data stratifying medication abortion (MAB) success rates by obesity class or multifetal gestation. With rising rates of class III obesity, it is important to assess the efficacy of current MAB protocols in this population. A 30-year-old G3P1011 at six weeks two days (6w2d) with a diamniotic, dichorionic twin gestation and a body mass index (BMI) of 53, elected for MAB. She received 200 mg oral mifepristone followed by two doses of 800 mcg buccal misoprostol over 48 hours. Minimal symptoms occurred initially, and she ultimately required manual vacuum aspiration 31 days later for retained products. This case highlights possible limitations of standard MAB regimens in class III obesity with twin gestation, suggesting altered pharmacokinetics and the need for further research to optimize care.

Indexed as

abortion failureclass iii obesityclinical pharmacokineticsextreme obesitymedication abortiontwin gestationwomen's health

Identifiers

PMID42158763
PMCPMC13183362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.