ArticleTranslational pediatrics2026
Relationship between gut microbiota establishment patterns and the risk of necrotizing enterocolitis in preterm infants: a retrospective cohort study.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Gut microbiota alterations in Neonatal Intensive Care Unit extremely preterm infants: a Chinese tertiary center study.Translational pediatrics · 2026Article
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3 authors.
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Abstract
Background: Necrotizing enterocolitis (NEC) is one of the most severe gastrointestinal emergencies in preterm infants (PIs), and gut dysbiosis plays an important role in its pathogenesis. This study aimed to investigate the relationship between gut microbiota establishment patterns and the risk of NEC in PIs, analyze risk factors influencing microbiota establishment, and provide scientific evidence for the early prevention of NEC. Methods: In this retrospective cohort study, data of 174 PIs admitted between January 2023 and December 2024 were analyzed, including 58 cases in the NEC group and 116 cases in the control group (CG). 16S rRNA high-throughput sequencing was used to analyze the gut microbiota composition at 3, 7, 14, and 21 days after birth. The Shannon index and Simpson index were calculated to assess microbiota diversity. The relative abundance of major genera including Results: The NEC group showed significantly lower gestational age and birth weight than the CG (P<0.05). At 14 days after birth, the NEC group exhibited significantly lower Shannon index and Simpson index than the CG (P<0.05). The relative abundances of Conclusions: Reduced gut microbiota diversity, decreased beneficial bacteria, and increased pathogenic bacteria in PIs are closely associated with the occurrence of NEC. Early monitoring of gut microbiota changes, appropriate antibiotic use, promotion of breastfeeding, and supplementation with probiotics may reduce the risk of NEC.
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