ArticleTranslational pediatrics2026
Single-cell RNA sequencing reveals extensive fibrotic remodeling and pathogenic chondrocyte subpopulations in developmental dysplasia of the hip.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Developmental dysplasia of the hip (DDH) is a common pediatric orthopedic disorder that predisposes affected children to early-onset osteoarthritis (OA), yet the cellular heterogeneity and fibrotic remodeling of acetabular cartilage are poorly understood. Methods: We performed single-cell RNA sequencing (scRNA-seq) on acetabular cartilage obtained from three children with DDH and two age-matched controls, thereby generating a transcriptomic atlas of 10,550 chondrocytes. Results: Nine chondrocyte subpopulations were identified, including four previously unrecognized subsets (C1-C4). Compared with controls, DDH cartilage exhibited a marked shift toward fibrocartilage-like phenotypes, characterized by upregulation of fibrotic and matrix-remodeling genes, such as Conclusions: These findings reveal molecular remodeling of cartilage obtained from dislocated hips in DDH and identify fibrosis-associated chondrocyte subpopulations that may contribute to early degenerative changes.
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