ArticleFrontiers in surgery2026
Serum CitH3 and TSLP as predictive biomarkers for impaired wound healing after bascom cleft lift surgery in pilonidal sinus disease: a nomogram-based risk model.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the predictive value of serum citrullinated histone H3 (CitH3) and thymic stromal lymphopoietin (TSLP) for postoperative wound healing outcomes in patients with pilonidal sinus (PS), and to construct a nomogram-based risk prediction model. Methods: This prospective observational study enrolled 181 patients with PS who underwent Bascom cleft lift between November 2022 and August 2025. According to wound-healing status at 6 weeks postoperatively, patients were classified into a good-healing group ( Results: Wound-healing impairment occurred in 26 patients (14.36%). Compared with the good-healing group, the poor-healing group exhibited significantly higher body-mass index (BMI), fasting blood glucose (FBG), C-reactive protein (CRP), CitH3 and TSLP levels, together with significantly lower albumin (ALB) levels (all Conclusion: Elevated serum CitH3 and TSLP levels are closely associated with impaired wound healing after Bascom cleft lift for PS and demonstrate favorable predictive performance. The nomogram developed in this study holds promise as a reference tool for individualized risk assessment and clinical decision-making; however, its clinical utility warrants validation through multicenter, large-scale investigations.
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