ArticleFrontiers in oncology2026
Risk factors and predictive model for cervical lymph node metastasis in papillary thyroid carcinoma of the isthmus: a retrospective analysis of clinical and ultrasonographic features.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate the clinical and ultrasonographic characteristics of papillary thyroid carcinoma (PTC) located in the thyroid isthmus and to identify independent risk factors predicting cervical lymph node metastasis (LNM). Methods: We retrospectively analyzed 445 patients with pathology-confirmed isthmic PTC who underwent surgery at Lishui Central Hospital between December 2020 and August 2025. Based on postoperative histopathology, patients were categorized into LNM (n=160) and non-LNM (n=285) groups. Clinical and preoperative ultrasonographic features were compared between groups. Univariate and multivariate logistic regression analyzes were performed to identify independent risk factors for LNM. A predictive model was constructed and evaluated using receiver operating characteristic (ROC) curve analysis. Results: Compared to the non-LNM group, patients in the LNM group were significantly younger (median age: 44.0 vs. 49.0 years, P = 0.012), had a higher proportion of females (70.0% vs. 62.1%, P = 0.018), and presented with larger tumors (median diameter: 9.5 vs. 6.0 mm, P < 0.001). Multivariate analysis identified maximum tumor diameter (OR = 1.15, 95% CI: 1.09-1.22, P < 0.001), female gender (OR = 1.82, 95% CI: 1.20-2.76, P = 0.004), and the presence of microcalcifications on ultrasound (OR = 1.58, 95% CI: 1.02-2.45, P = 0.040) as independent risk factors for LNM. The predictive model integrating these three factors yielded an area under the ROC curve (AUC) of 0.799 (95% CI: 0.762-0.837), with a sensitivity of 81.2% and a specificity of 66.7% at the optimal cutoff. Conclusion: Tumor size, female gender, and the presence of microcalcifications are independent preoperative risk factors for cervical LNM in isthmic PTC. A model based on these clinically accessible parameters provides a practical tool for preoperative risk assessment, which could help guide more individualized surgical management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.