Evidence map›Paper›PMID 42158424›Full record

ArticleFrontiers in oncology2026

CD38

Ieva Ailte, Sudhir Kumar Chauhan, Lina Prasmickaite, Assia V Bassarova, Amanda Poissonnier, Marike Feenstra, Marta Nyakas, Bjarne Johannessen, Truls Ryder, Robert Hermann and 8 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ieva AilteDepartment of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Sudhir Kumar ChauhanDepartment of Cancer Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Lina PrasmickaiteDepartment of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Assia V BassarovaDepartment of Pathology, Division of Laboratory Medicine, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Amanda PoissonnierDepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, United States.
Marike FeenstraDepartment of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Marta NyakasDepartment of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Bjarne JohannessenDepartment of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Truls RyderDepartment of Oncologic Plastic Surgery, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Robert HermannDepartment of Oncologic Plastic Surgery, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Lars FrichDepartment of Oncologic Plastic Surgery, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Arild HolthDepartment of Pathology, Division of Laboratory Medicine, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Else Marit InderbergSection for Cellular Therapy, Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Henrik JespersenDepartment of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Vivi Ann FlørenesDepartment of Pathology, Division of Laboratory Medicine, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Jon Amund Kyte *Department of Cancer Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Gunhild M Mælandsmo *Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Eivind Valen EgelandDepartment of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adjuvant immune checkpoint inhibitors (ICI) have improved survival in stage III cutaneous melanoma, yet many patients do not benefit. The tumor microenvironment is pivotal for durable responses; defining cellular composition can pinpoint immune components promoting anti-tumor activity and identify biomarkers associated with improved outcomes. Method: Regional lymph nodes (RLNs) were obtained at surgery from 29 patients with stage III melanoma. Eligible patients received adjuvant anti-PD-1 (αPD-1; pembrolizumab or nivolumab). Mass cytometry (CyTOF) was used to determine cellular composition of pre-treatment surgical specimens. NanoString bulk gene expression data from 125 patients receiving surgery without adjuvant therapy were used to evaluate trends observed in the CyTOF dataset. Results: Higher proportions of CD103 Conclusion: Baseline infiltration of CD8

Indexed as

CD103+PD-1+CD8+ T cellsCD38hiCD19dimimmune checkpoint inhibitorsPD1-blockadeplasmablast-like cellsstage III melanoma

Identifiers

PMID42158424
PMCPMC13180574

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.