ArticleFrontiers in veterinary science2026
Rumen-protected guanidinoacetic acid is associated with improved growth performance and altered portal nutrient and hepatic IGF-1 indices in Hu sheep.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Guanidinoacetic Acid and Cysteamine Hydrochloride Improve Beef Cattle Growth and Antioxidant Capacity via Fecal Microbiome and Serum Metabolome.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Effects of rumen-protected guanidinoacetic acid on fat deposition, antioxidant capacity, fatty acid profiles in subcutaneous adipose of Tibetan sheep: integrated RNA-seq and LC-MS/MS analysis.Frontiers in veterinary science · 2026Article
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5 authors.
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Abstract
Introduction: Guanidinoacetic acid (GAA), the direct precursor of creatine, has been shown to improve growth performance in monogastric animals, but its metabolic effects in ruminants remain unclear. This study examined whether dietary GAA and rumen-protected GAA (RPGAA) are associated with changes in intestinal creatine-related metabolism, portal nutrient concentrations, and hepatic IGF-1 expression in Hu sheep. Methods: Twenty-seven Hu rams were randomly assigned to three treatments for 45 days: a basal diet (control), the basal diet supplemented with 1.0 g/kg GAA, or the basal diet supplemented with 1.0 g/kg RPGAA. Growth performance, intestinal mucosal GAA and creatine concentrations, expression of genes related to creatine metabolism and nutrient transport, portal blood nutrient concentrations, serum biochemical variables, and hepatic IGF-1 indices were determined. Results: RPGAA significantly increased final body weight and average daily gain and decreased feed-to-gain ratio ( Discussion: These findings suggest that the improved growth performance induced by RPGAA is associated with enhanced jejunal GAA availability, portal nutrient concentrations, and hepatic IGF-1 expression in Hu sheep.
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