Evidence map›Paper›PMID 42158235›Full record

ArticleScientifica2026

Antibacterial and Anti-Inflammatory Properties of

Sri Mulyanti, Dewi Sodja Laela, Pramesthi Reitza Navisya Vasall, Nandang Permadi, Dudi Aripin, Amaliya Amaliya, Yaya Rukayadi, Euis Julaeha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientifica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sri MulyantiDoctorate Program in Biotechnology, Graduate School, Universitas Padjadjaran, Bandung, 40135, Indonesia, unpad.ac.id.ORCID https://orcid.org/0009-0001-8850-7302
Dewi Sodja LaelaPoliteknik Kesehatan Kemenkes, Bandung, 40271, Indonesia.ORCID https://orcid.org/0000-0001-9796-8437
Pramesthi Reitza Navisya VasallDoctorate Program in Biotechnology, Graduate School, Universitas Padjadjaran, Bandung, 40135, Indonesia, unpad.ac.id.ORCID https://orcid.org/0009-0005-9804-6692
Nandang PermadiResearch Center for Food Crops, Research Organization for Agriculture and Food, National Research and Innovation Agency, Cibinong, 16911, Indonesia, brin.go.id.ORCID https://orcid.org/0000-0002-9569-0627
Dudi AripinDepartment of Conservative Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Jatinangor, 45363, Indonesia, unpad.ac.id.ORCID https://orcid.org/0000-0002-0669-1936
Amaliya AmaliyaDepartment of Periodontology, Faculty of Dentistry, Universitas Padjadjaran, Jatinangor, 45363, Indonesia, unpad.ac.id.ORCID https://orcid.org/0000-0002-9164-0542
Yaya RukayadiDepartment of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, 43400, Malaysia, upm.edu.my.ORCID https://orcid.org/0000-0001-7807-4462
Euis JulaehaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia, unpad.ac.id.ORCID https://orcid.org/0000-0002-5822-3763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Periodontal disease is one of the most prevalent oral health problems in Indonesia. According to the 2018 National Basic Health Research (RISKESDAS), its prevalence ranges from 73.1% to 75%. The primary cause is dental plaque accumulation, which can be removed chemically using mouthwash. However, most commercial mouthwashes contain synthetic chemicals that may cause adverse effects on oral tissues when used long term. This study aimed to develop a natural-based mouthwash formulation from the essential oil of lime peel ( Methods: The essential oil was obtained by hydrodistillation and formulated into six mouthwash preparations. The antibacterial activity was assessed using agar disc diffusion for inhibition zones, while MIC and MBC were determined using the broth microdilution method. Physicochemical properties of the mouthwash, including pH, viscosity, and specific gravity, were also analyzed. The most effective formula was further tested in vivo on the gingiva of white rats ( Results: Formula IV, containing 0.8% essential oil, exhibited the strongest antibacterial activity, particularly against Conclusion: Formula IV represents a safe and effective natural-based mouthwash for the prevention of dental caries and gingivitis.

Indexed as

antibacterial effectanti-inflammatory effectC. aurantiifolia essential oilcytotoxicitymouthwash

Identifiers

PMID42158235
PMCPMC13181426

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.