ArticleInternational journal of chronic obstructive pulmonary disease2026
Impact of Nutritional Status and Sarcopenia on Acute Exacerbation Risk in Stable Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) drive disease progression and mortality. This study aims to investigate whether nutritional risk and sarcopenia independently predict (AECOPD) in patients with stable COPD. Methods: In this single-center retrospective cohort study, 264 hospitalized patients with stable COPD were followed for 12 months. Nutritional risk was assessed using the Nutritional Risk Screening 2002. Sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019 criteria. Appendicular skeletal muscle index (ASMI), handgrip strength, gait speed, and five-repetition sit-to-stand (5STS) time were measured. Independent predictors of AECOPD were identified using multivariable logistic regression. Discrimination was evaluated using the area under the receiver operating characteristic curve (AUC). Results: During follow-up, 102 patients (38.6%) developed AECOPD. Patients with AECOPD exhibited higher rates of sarcopenia (64.71% vs. 32.72%, Conclusion: Sarcopenia and nutritional risk independently increase AECOPD risk in stable COPD. Incorporating muscle mass parameters into risk stratification may improve predictive accuracy.
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