ReviewFrontiers in public health2026
The impact of Di(2-ethylhexyl) phthalate on human organ development: mechanisms and clinical relevance review.
Review in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer that has raised significant concerns due to its strong endocrine-disrupting effects, which are closely associated with developmental toxicity. While previous reviews have explored DEHP's developmental toxicity, this study uniquely focuses on recent (past 10 years) advances in understanding the molecular mechanisms behind DEHP-induced organ developmental disorders. It emphasizes key pathways involved in cellular proliferation, differentiation, and endocrine balance. Despite widespread human exposure to DEHP, translating preclinical findings to human health outcomes remains challenging due to variations in exposure levels, individual susceptibility, and limited clinical data. This review compiles the latest clinical research on DEHP-related developmental health risks, explicitly addressing these uncertainties and exposure-related factors. By combining new molecular insights with clinical relevance, this review offers a focused scientific basis for future research into DEHP's developmental toxicology, bridging the gap between preclinical mechanisms and real-world human exposure outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.