SynthesisFrontiers in medicine2026
Ferroptosis inhibition as a renoprotective strategy in cisplatin-induced acute kidney injury: multilevel meta-analysis of mechanistic biomarkers.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Echinacoside Alleviates Cisplatin-Induced Acute Kidney Injury by Regulating Bap1 to Inhibit Ferroptosis.Biomedicines · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cisplatin-induced acute kidney injury (CI-AKI) is a severe, dose-limiting nephrotoxicity affecting up to 30% of patients. Emerging evidence highlights ferroptosis-an iron-dependent form of regulated cell death-as a key mechanism in cisplatin-induced tubular damage. However, the overall effectiveness of various ferroptosis inhibitors remains unclear. This study aims to synthesise preclinical evidence to assess the renoprotective potential of natural and synthetic agents targeting the ferroptotic cascade. Methods: Following PRISMA 2020 guidelines, a systematic review and multilevel meta-analysis were conducted across PubMed and Web of Science. From 58 unique preclinical studies (265 effect sizes), we extracted data on renal function (BUN, SCr) and ferroptotic biomarkers (GPX4, GSH, MDA, 4-HNE, Fe Results: Both natural and synthetic interventions significantly alleviated renal dysfunction, markedly reducing BUN (Intercepts Conclusion: Inhibition of ferroptosis is a promising preclinical strategy to mitigate CI-AKI, with restoration of the System Xc-/GSH/GPX4 axis emerging as the primary mechanistic driver of renoprotection. These results provide a quantitative mechanistic consensus supporting further investigation and clinical development of ferroptosis-targeted adjuvants to widen the therapeutic window of cisplatin-based chemotherapy.
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