ArticleFrontiers in medicine2026
From persistent hypercalcemia to parathyroid carcinoma: a case report of acute urinary retention and the diagnostic role of Ki-67.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Parathyroid carcinoma (PC) is a rare and often misdiagnosed endocrine malignancy that can present with diverse clinical manifestations, complicating its detection and management. Case presentation: This case report presents a 59-year-old male diagnosed with parathyroid carcinoma (PC), initially misidentified as benign parathyroid hyperplasia and adenoma. Over the course of 4 years, the patient underwent three surgical interventions. Final surgery confirmed the definitive diagnosis of PC, which revealed vascular invasion. The patient exhibited unusual clinical manifestations, notably severe hypercalcemia leading to acute urinary retention (AUR), which posed a diagnostic challenge. Pathological evaluation indicated a Ki-67 proliferation index of 8%, raising concerns about malignancy. This case highlights the need for multidisciplinary collaboration in the diagnostic process, recognizing atypical symptoms and carefully interpreting histopathological markers in suspected PC cases. Conclusion: Persistent hyperparathyroidism, elevated Ki-67 levels, and unexplained lower urinary tract symptoms (LUTS) should prompt re-evaluation for malignancy, highlighting the rarity yet clinical significance of hypercalcemia-induced AUR as a presenting symptom of underlying parathyroid pathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.