The impact of sedation depth on the occurrence of delirium and prognosis in intensive care unit patients: a meta-analysis.

Background: Delirium and poor clinical prognoses are prevalent among ICU patients, particularly those requiring mechanical ventilation. While sedation is a cornerstone of intensive care, the impact of its depth remains controversial; deep sedation is often linked to adverse outcomes, whereas light sedation may improve recovery trajectories. We conducted a systematic review and meta-analysis to clarify the association between sedation depth and delirium incidence, mortality, and ICU length of stay (LOS). Methods: Following PRISMA 2020 guidelines and PROSPERO registration (CRD420251054377), we searched PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials (RCTs) and cohort studies published through June 17, 2025. Two reviewers independently performed data extraction and quality assessment using RoB 2 for RCTs and the Newcastle-Ottawa Scale (NOS) or ROBINS-I for non-randomized studies. Evidence quality was evaluated using the GRADE framework. Results: Eleven studies (6 RCTs, 5 cohorts) involving 3,466 patients were included. Meta-analysis using a fixed-effects model demonstrated that deep sedation was significantly associated with a higher incidence of delirium (OR: 1.34; 95% CI: 1.15-1.57; Conclusion: Deep sedation is significantly associated with an increased risk of delirium, higher mortality, and extended ICU stays. While these associations are consistent across study designs, clinicians should account for the multifactorial influences on these outcomes. Implementing sedation protocols that prioritize lighter sedation depth may be associated with improved ICU patient prognoses. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251054377, identifier CRD420251054377.