Association of uric acid levels with the risk of severe CED in LVO-AIS patients after mechanical thrombectomy.

Mayila Abuduaini, Xinli Xiong, Gang Li, Tianrui Zhu, Yaling Zheng, Qi Wang, Zhengyu Huang, Yue Zhang

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Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Mayila Abuduaini *Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Xinli Xiong *Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Gang LiDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Tianrui ZhuDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Yaling ZhengDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Qi WangDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Zhengyu HuangDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Yue ZhangDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Cerebral edema (CED) significantly exacerbates mortality in patients with acute ischemic stroke (AIS) and can offset the benefits of endovascular therapy. Uric acid (UA) is recognized for its potential neuroprotective properties. This study aimed to investigate the association between serum UA levels and moderate-to-severe CED in large-vessel occlusion (LVO-AIS) patients following mechanical thrombectomy (MT). Methods: We retrospectively analyzed 272 patients with anterior circulation LVO-AIS who achieved successful reperfusion (mTICI grade 2b-3) after MT. Patients were categorized into mild and moderate-to-severe CED groups, Multivariate logistic regression and interaction analyses were employed to determine the relationship between UA levels and the risk of moderate-to-severe CED. Results: Patients in the no-to-mild CED group exhibited significantly higher UA levels compared to the moderate-to-severe CED group (median 310.0 vs. 302.0 μmol/L; Conclusion: Higher serum UA levels may serve as a protective factor against moderate-to-severe CED following MT in LVO-AIS patients. This association is particularly significant in patients with lower glucose levels, optimal reperfusion (mTICI 3), and a history of hypertension.

Indexed as

acute ischemic strokecerebral edemalarge vascular occlusionmechanical thrombectomyuric acid

Identifiers

PMID42158013

DOI10.3389/fneur.2026.1773323

PMCPMC13181920

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