Evidence map›Paper›PMID 42157965›Full record

ArticleMolecular therapy. Advances2026

Gene therapy rescues cone function in

Marion E Cahill, Kathryn Chmelik, Madyson E Ashcraft, Brooke A Brothers, Tongju Guan, Jonathan Nguyen, Artjola Puja, Mark Eminhizer, Lee M Shaw, Robert J Barbera and 3 more

Abstract read
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marion E CahillDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.
Kathryn ChmelikDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506, USA.
Madyson E AshcraftDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506, USA.
Brooke A BrothersDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.
Tongju GuanDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506, USA.
Jonathan NguyenDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.
Artjola PujaDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.
Mark EminhizerDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.
Lee M ShawDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506, USA.
Robert J BarberaDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506, USA.
Emily R SechrestDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506, USA.
Jianhai DuDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.
Wen-Tao DengDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506, USA.

Funding

VS-CoBRE Administrative CoreP20GM144230 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Visvanathan Ramamurthy · 2022 to 2026
$13.9M
Disease mechanisms of cone opsin mutants and treatment strategiesR01EY030056 · NEI · WEST VIRGINIA UNIVERSITY · PI DENG, WEN-TAO · 2019 to 2023
$1.9M
NEI NIH HHS R01 EY030056NIGMS NIH HHS P20 GM144230
6 · The paper itself

Abstract

Blue cone monochromacy (BCM) is a congenital vision disorder caused by the loss of L- and M-cone function, leading to severe loss of visual acuity and color perception deficits. To test gene therapy for BCM in a model that mimics the densely packed foveal cones of human retinas, we generated a triple knockout (TKO) mouse model (

Indexed as

AAVblue cone monochromacycone dystrophycone opsinfoveagene therapymacula

Identifiers

PMID42157965
PMCPMC13182793

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.