Evidence map›Paper›PMID 42157961›Full record

ArticleMolecular therapy. Advances2026

Normothermic perfusion of human livers for profiling lentiviral vector pharmacokinetics and transduction.

Brannon R M Nicholls, David Johnson, Anurag Kulkarni, Rui André Saraiva Raposo, Kyriacos A Mitrophanous, Constantin C Coussios, Robert C Carlisle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brannon R M NichollsInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Botnar 3 Research Building, Windmill Road, Headington, Oxford OX3 7LD, UK.
David JohnsonInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Botnar 3 Research Building, Windmill Road, Headington, Oxford OX3 7LD, UK.
Anurag KulkarniOxford Biomedica (UK) Ltd, Windrush Court, Transport Way, Oxford OX4 6LT, UK.
Rui André Saraiva RaposoOxford Biomedica (UK) Ltd, Windrush Court, Transport Way, Oxford OX4 6LT, UK.
Kyriacos A MitrophanousOxford Biomedica (UK) Ltd, Windrush Court, Transport Way, Oxford OX4 6LT, UK.
Constantin C CoussiosInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Botnar 3 Research Building, Windmill Road, Headington, Oxford OX3 7LD, UK.
Robert C CarlisleInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Botnar 3 Research Building, Windmill Road, Headington, Oxford OX3 7LD, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lentiviral vectors (LVs) hold significant potential for gene therapy (GT) due to their ability to integrate into non-dividing cells, potentially offering lifelong cures from a single dose. The liver is an attractive GT target due to its role in inherited disorders and as a sink for intravenously delivered therapeutics. However, clinical translation of LV therapy remains challenging due to the poor predictive value of animal models. Normothermic machine perfusion (NMP) maintains human organs under physiological conditions

Indexed as

ex vivogene therapylentiviral vectorliverliver-directed gene therapynormothermic machine perfusionpharmacodynamicspharmacokineticspre-clinical model

Identifiers

PMID42157961
PMCPMC13182791

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.