Evidence map›Paper›PMID 42157959›Full record

ArticleMolecular therapy. Advances2026

RAAVioli: A comprehensive approach to characterizing AAV vector integrations and rearrangements.

Carlo Cipriani, Laura Rudilosso, Dhwanil A Dalwadi, Marco Masseroli, Markus Grompe, Eugenio Montini, Andrea Calabria, Daniela Cesana

Abstract read
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlo CiprianiDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy.
Laura RudilossoSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Dhwanil A DalwadiPapé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA.
Marco MasseroliDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy.
Markus GrompePapé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA.
Eugenio MontiniSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Andrea CalabriaSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Daniela CesanaSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we validated recombinant adeno-associated viral integration analysis (RAAVioli), a previously published computational method for the comprehensive analysis of adeno-associated virus vector (AAV) integration sites (ISs) and vector rearrangements across both long- and short-read sequencing platforms. Through

Indexed as

AAVbioinformaticsgene therapyintegrationslong- and short read sequencingpipeline

Identifiers

PMID42157959
PMCPMC13182792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.