Evidence map›Paper›PMID 42157957›Full record

ArticleKnowledge and information systems2026

Automated biomedical hypothesis generation with time-aware hypergraph contrastive learning.

Amir Hassan Shariatmadari, Sikun Guo, Nathan C Sheffield, Aidong Zhang, Kishlay Jha

Abstract read
In one paragraph

Article in Knowledge and information systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amir Hassan ShariatmadariDepartment of Computer Science, University of Virginia, 85 Engineer's Way, Charlottesville, Virginia 22903 USA.
Sikun GuoDepartment of Computer Science, University of Virginia, 85 Engineer's Way, Charlottesville, Virginia 22903 USA.
Nathan C SheffieldDepartment of Genome Sciences, University of Virginia, 1335 Lee Street, Charlottesville, Virginia 22903 USA.
Aidong ZhangDepartment of Computer Science, University of Virginia, 85 Engineer's Way, Charlottesville, Virginia 22903 USA.
Kishlay JhaDepartment of Electrical and Computer Engineering, University of Iowa, 4324 Seamans Center for the Engineering Arts and Sciences, Iowa City, Iowa 52242 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research in scientific domains now generates more than a million articles annually, overwhelming researchers and hindering discovery. This surge has sparked interest in biomedical hypothesis generation (HG), which aims to uncover implicit patterns among biomedical concepts. Most existing methods focus on pairwise link prediction, overlooking the complex, multi-concept relationships underlying many breakthroughs. We introduce

Indexed as

HypergraphsHypothesis generationTemporal graph learning

Identifiers

PMID42157957
PMCPMC13180762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.