Evidence map›Paper›PMID 42157949›Full record

ArticleInternational journal of biological sciences2026

HDAC7-Induced Epigenetic Repression Modulates ATF3 Functional Plasticity in Colorectal Cancer Pathogenesis.

Qi Wang, Donglei Ji, Yanjie Jia, Shuang Li, Wenjing Gao, Tingting Liang, Yingying Liang, Caroline Zeng, Chunyu Wang, Ka Lung Cheung and 3 more

Abstract read
PubMed Full text at PMC Publisher
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Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qi WangBethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Donglei JiBethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Yanjie JiaBethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Shuang LiDepartment of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Wenjing GaoBethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Tingting LiangBethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Yingying LiangBethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Caroline ZengPennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Chunyu WangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, China.
Ka Lung CheungDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Quan WangDepartment of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Ming-Ming ZhouDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Lei ZengBethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Class IIa histone deacetylase 7 (HDAC7) regulates transcription primarily through scaffolding functions, but its molecular mechanisms in cancer pathogenesis remain incompletely understood. Here, we establish HDAC7 as a key epigenetic regulator in colorectal cancer (CRC). HDAC7 is overexpressed in CRC tumors and correlates with advanced disease stages, lymph node metastasis, and poor patient survival. Mechanistically, HDAC7 scaffolds a repressive complex with HDAC3 and the stress-responsive transcription factor ATF3. This reduces H3K27ac/H3K18ac occupancy and blocks BRD4/RNA polymerase II (Pol II) recruitment at

Indexed as

Activating Transcription Factor 3Colorectal NeoplasmsEpigenetic RepressionHistone DeacetylasesAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHistone Deacetylase 3HumansMiceSignal TransductionTranscription FactorsActivating Transcription Factor 3ATF3 protein, humanHDAC7 protein, humanHistone Deacetylase 3Histone DeacetylasesTranscription FactorsATF3class IIa HDACcolorectal cancerepigenetic repressionHDAC7scaffold protein

Identifiers

PMID42157949
PMCPMC13182534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.