Evidence map›Paper›PMID 42157939›Full record

ArticleInternational journal of biological sciences2026

Canagliflozin and Brusatol Synergize against LKB1-KEAP1 Co-Mutant NSCLC through AKT Suppression.

Yiguan Chen, Xiang-Zheng Gao, Dade Rong, Liangliang Gao, Mingzhu Tang, Guang Lu, Zhi-Qiang Ling, Han-Ming Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiguan ChenFaculty of Health Sciences, Ministry of Education Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR, China.
Xiang-Zheng GaoFaculty of Health Sciences, Ministry of Education Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR, China.
Dade RongFaculty of Health Sciences, Ministry of Education Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR, China.
Liangliang GaoFaculty of Health Sciences, Ministry of Education Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR, China.
Mingzhu TangFaculty of Health Sciences, Ministry of Education Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR, China.
Guang LuDepartment of Physiological Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Zhi-Qiang LingZhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Han-Ming ShenFaculty of Health Sciences, Ministry of Education Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver kinase B1 (LKB1, encoded by

Indexed as

CanagliflozinCarcinoma, Non-Small-Cell LungKelch-Like ECH-Associated Protein 1Lung NeoplasmsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktQuassinsAMP-Activated Protein Kinase KinasesAnimalsApoptosisCell Line, TumorHumansMiceMice, NudeMutationNF-E2-Related Factor 2AMP-Activated Protein Kinase KinasesbrusatolCanagliflozinKEAP1 protein, humanKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Protein Serine-Threonine KinasesProto-Oncogene Proteins c-aktQuassinsSTK11 protein, humanBrusatolCanagliflozinKEAP1LKB1NRF2NSCLC

Identifiers

PMID42157939
PMCPMC13182243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.