Evidence map›Paper›PMID 42157936›Full record

ArticleInternational journal of biological sciences2026

METTL3-IGF2BP3 as a glucose sensor in hyperglycemic microenvironment promotes tumorigenesis and glycolysis.

Long Liu, Yu Zhang, Zhiwei Shao, Xiaohong Zhao, Yuxi Huang, Qi Wang, Xingyu Liu, Xiang Zheng, Bo Zhou, Fabiao Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Long LiuDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Yu ZhangDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230001, China.
Zhiwei ShaoDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Xiaohong ZhaoSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 310000, China.
Yuxi HuangDepartment of Hepatobiliary and Pancreatic Surgery, Taizhou Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317000, China.
Qi WangDepartment of Hepatobiliary and Pancreatic Surgery, Taizhou Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317000, China.
Xingyu LiuDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Xiang ZhengDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Bo ZhouDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Fabiao ZhangDepartment of Hepatobiliary and Pancreatic Surgery, Taizhou Hospital, Zhejiang University School of Medicine, Taizhou, Zhejiang, 317000, China.
Zhenzhen GaoDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Sheng YanDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycemic disorders, especially diabetes characterized by elevated blood glucose, significantly increase the risk of various cancers, including increasing the risk of hepatocellular carcinoma (HCC) by 239%. Diabetes mellitus has now been confirmed as an independent risk factor for the development of HCC, with T2DM increasing the risk by 4.59 times. However, little is known about mechanisms regulate glucose signal transduction in HCC. We investigated the relationship between high glucose levels and methylation-related gene expression in HCC. The effects of METTL3-IGF2BP3 on transcriptome profiles were used to identify downstream molecules. Proliferation, glucose uptake, lactate production, ATP levels, extracellular acidification rate, and oxygen consumption rate were examined in HCC cells. The mechanism by which METTL3-IGF2BP3 activates the PI3K-AKT pathway was explored. The results showed that m

Indexed as

Carcinoma, HepatocellularGlucoseHyperglycemiaLiver NeoplasmsMethyltransferasesRNA-Binding ProteinsAnimalsCarcinogenesisCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticGlycolysisHumansMetabolic ReprogrammingRNA MethylationSignal TransductionGlucoseIGF2BP3 protein, humanMethyltransferasesMETTL3 protein, humanRNA-Binding ProteinsGlucoseHepatocellular carcinomaIGF2BP3MethylationMETTL3

Identifiers

PMID42157936
PMCPMC13181852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.