Evidence map›Paper›PMID 42157932›Full record

ArticleInternational journal of biological sciences2026

Synonymous editing alters ion channel function, favoring prime editing for retinal disease correction.

Meha Kabra, Mariya Moosajee, Ana Navarrete, Gregory A Newby, Piper Rawding, Ruosen Xie, Hadas Mechoulam, Antonio Rivera, Alan Hung, Smriti Tiwari and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Meha KabraDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, United States.
Mariya MoosajeeDevelopment, Ageing, and Disease, University College London (UCL) Institute of Ophthalmology, London, EC1V 9EL, United Kingdom.
Ana NavarreteDepartment of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.
Gregory A NewbyMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, United States.
Piper RawdingMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, United States.
Ruosen XieMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, United States.
Hadas MechoulamDepartment of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.
Antonio RiveraDepartment of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.
Alan HungDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, United States.
Smriti TiwariDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, United States.
Adam J WaxmanDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, United States.
Kaivalya MoluguDepartment of Biomedical Engineering, Wisconsin Institute of Discovery, University of Wisconsin-Madison, Madison, WI 53706, United States.
Krishanu SahaDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, United States.
Shaoqin GongMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI 53705, United States.
David R LiuMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, United States.
Bikash R PattnaikDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, United States.

Funding

The CRISPR Vision Program: Nonviral Genome Editing Platforms to Treat Inherited Retinal Channelopathies Epqt SupplementU19NS132296 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Krishanu Saha · 2023 to 2026
$36.8M
Restoring Vision with High-Fidelity Nonsense Codon CorrectionR24EY032434 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AHERN, CHRISTOPHER A, GAMM, DAVID M · 2021 to 2025
$7.8M
Molecular Therapies for Lebers Congenital Amaurosis Caused by KCNJ13 MutationsR01EY024995 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PATTNAIK, BIKASH RANJAN · 2015 to 2018
$1.5M
NEI NIH HHS R01 EY024995NEI NIH HHS R24 EY032434NINDS NIH HHS U19 NS132296
6 · The paper itself

Abstract

Point mutations in the

Indexed as

Gene EditingLeber Congenital AmaurosisPotassium Channels, Inwardly RectifyingRetinal DiseasesHEK293 CellsHumansMutation, MissenseRetinal Pigment EpitheliumKir7.1 channelPotassium Channels, Inwardly Rectifyingadenine base editingCRISPR base editingcytosine base editinggenetic disordershuman iPSC-derived retinal pigmented epithelium (RPE)ion channelopathyKCNJ13 mutationKir7.1LCA16 pediatric blindnessprime editingstable cells.synonymous variations

Identifiers

PMID42157932
PMCPMC13182245

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.