Evidence map›Paper›PMID 42157926›Full record

ArticleInternational journal of biological sciences2026

Elucidating Tumorigenesis Mechanisms and Assessing Immunotherapeutic Efficacy in Patient-Derived Medulloblastoma Organoid Models.

Jiting Zhang, Min Wang, Huanwen Rui, Cen Wang, Guanghao Luo, Zhiyuan Niu, Wei Shi, Junwei Zeng, Ping Xue, Xueyao Shi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiting ZhangState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China.
Min WangDepartment of Neurosurgery, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Huanwen RuiDepartment of Neurosurgery, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Cen WangState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China.
Guanghao LuoState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China.
Zhiyuan NiuState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China.
Wei ShiDepartment of Neurosurgery, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Junwei ZengState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China.
Ping XueDepartment of Neurosurgery, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xueyao ShiState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institute of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Bing YanState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China.
Wenyan RenJiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Cambridge-Suda Genomic Resource Center, Suzhou Medical College of Soochow University, Suzhou, China.
Hao LiDepartment of Neurosurgery, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xinhua LinState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medulloblastoma is one of the most common malignant pediatric brain tumors. There remain significant challenges in investigating oncogenic mechanisms and evaluating therapeutic efficacy due to the limited available models that accurately reflect tumor heterogeneity. To overcome this limitation, we established 10 patient-derived medulloblastoma organoids (MBOs) that retain the histological characteristics, and cellular diversity of the original tumors. These MBOs demonstrate strong infiltration capabilities, both

Indexed as

CarcinogenesisCerebellar NeoplasmsImmunotherapyMedulloblastomaOrganoidsAnimalsCoculture TechniquesDNA MethylationHumansMiceTumor Microenvironmentimmunotherapymedulloblastomaorganoidssingle-cell sequencingtumorigenesis

Identifiers

PMID42157926
PMCPMC13182545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.