ArticlePeerJ2026
Retinal editome profiling in mice reveals RNA editing in key developmental genes associated with retinitis pigmentosa.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Adenosine-to-inosine (A-to-I) RNA editing has been found to function in various neurological disorders; however, the role of A-to-I RNA editing in retinitis pigmentosa (RP) remains unclear. Methods: RNA editing profiles of mouse retinas at different developmental stages, and three RP mouse models that were sampled at the peak of photoreceptor cell death for each model were analyzed to identify significant RNA editing events and genes involved in development and RP pathogenesis. Data from two addtional RP models were used for validation. Key editing sites were validated by Sanger sequencing and dual-luciferase reporter assays. Results: Global A-to-I editing levels increased during normal retinal development, correlating with Conclusions: Our study reveals that A-to-I RNA editing is dynamically regulated during retinal development and profoundly altered in RP, implicating RNA editing as a novel layer of gene regulation in inherited retinal diseases.
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