ArticleChemical science2026
Iron-mediated reactions of gem-dihaloalkanes with α,β-unsaturated carbonyl compounds.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
The ability to harness divergent reactivity and selectively dictate product outcomes from simple precursors has been a longstanding challenge in organic chemistry, especially in radical chemistry. Herein, we developed a sustainable reaction model leveraging earth-abundant iron as a reductant and gem-dihaloalkanes as radical donors to convert commodity α,β-unsaturated compounds into β,γ-unsaturated compounds or cyclopropanes in a tunable manner. The formation of the former involves unusual radical-mediated 1,2-acyl migrations and the generation of the latter involves an intramolecular radical-radical coupling. Moreover, the chemoselectivity could be effectively controlled by the solvent effects. This study not only provides a practical platform for synthesizing functionalized building blocks but also unlocks novel reactivity modes for gem-dihaloalkanes, positioning them as key tools for sustainable radical-involved transformations.
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