ArticleInternational journal of genomics2026
Lipid Metabolism-Related Genes Define Prognosis and Therapeutic Targets in Thyroid Cancer.
Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Lipid Metabolism-Related Genes Define Prognosis and Therapeutic Targets in Thyroid Cancer.International journal of genomics · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Altered lipid metabolism is increasingly recognized as a driver of tumor progression, yet its specific role in thyroid cancer remains unclear. Methods: We combined Mendelian randomization with transcriptomic and single-cell analyses to identify lipid-related factors that contribute to thyroid cancer development. A lipid-metabolism gene signature was constructed to evaluate its prognostic value, and functional assays were used to examine the biological role of ACBD7. Results: Lipid-related metabolites showed genetic evidence of causal relevance to thyroid cancer. We identified a set of lipid-metabolism genes that were consistently dysregulated in tumors and developed a nine-gene signature that stratified patient prognosis with high accuracy. The high-risk group displayed stronger lipid pathway activation, a distinct immune landscape, and a higher Conclusions: Lipid metabolic dysregulation contributes to thyroid cancer progression and may help refine clinical risk assessment. The nine-gene signature and the functional relevance of ACBD7 highlight the potential of lipid-targeted strategies in future therapeutic development.
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