ReviewInternational journal of general medicine2026
The Mechanosensation-Metabolism-Inflammation Axis: The Central Role of Piezo1 and TRPV4 in Hypertension-Related Atherosclerosis.
Review in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Role of NLRP3 Inflammasome Inhibitors in Endothelial Dysfunction and Vascular Repair.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is a core independent risk factor for cardiovascular events. The abnormal hemodynamic microenvironment mediated by hypertension is a key initiating factor for its development and progression, and mechanosensitive ion channels are the core molecules connecting vascular mechanical forces to intracellular biochemical signals. Piezo1 and Transient Receptor Potential Vanilloid 4 (TRPV4), as important mechanosensitive ion channels in blood vessels, are widely expressed in vascular endothelial cells, smooth muscle cells, and immune cells. They can sense and be activated by abnormal circumferential stress and shear stress under hypertensive conditions. This review systematically synthesizes current evidence to test the central hypothesis that Piezo1 and TRPV4 form a functionally synergistic signaling axis, converting pathological mechanical forces into sustained Ca
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Registered trials
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