Evidence map›Paper›PMID 42157847›Full record

ArticleACS medicinal chemistry letters2026

Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues.

Esraa A Elhalawaty, Howida A Alseedy, John G Woodland, Kathryn J Wicht, Tarryn Swart, Gabriel W Rangel, Heinrich C Hoppe, Kelly Chibale, Manuel Llinás, Ashraf H Abadi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Esraa A ElhalawatyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.
Howida A AlseedyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.
John G WoodlandDepartment of Chemistry, University of Cape Town, Cape Town 7700, South Africa.ORCID https://orcid.org/0000-0001-6273-5596
Kathryn J WichtDepartment of Chemistry, University of Cape Town, Cape Town 7700, South Africa.ORCID https://orcid.org/0000-0001-6145-9956
Tarryn SwartDept. of Biochemistry, Microbiology & Bioinformatics, Rhodes University, Makhanda 6139, South Africa.
Gabriel W RangelDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Heinrich C HoppeDept. of Biochemistry, Microbiology & Bioinformatics, Rhodes University, Makhanda 6139, South Africa.ORCID https://orcid.org/0000-0003-4409-1955
Kelly ChibaleDepartment of Chemistry, University of Cape Town, Cape Town 7700, South Africa.ORCID https://orcid.org/0000-0002-1327-4727
Manuel LlinásDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Ashraf H AbadiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.ORCID https://orcid.org/0000-0002-7433-261X
Nermin S AhmedDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.ORCID https://orcid.org/0000-0002-8869-3387

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Analogues of tadalafil, an FDA-approved inhibitor of human phosphodiesterase 5, have been reported to block the growth of human

Indexed as

diastereomersMalariametabolomicsPhosphodiesterasetetrahydro-β-carbolineβ-hematin

Identifiers

PMID42157847
PMCPMC13181485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.