Evidence map›Paper›PMID 42157841›Full record

ArticleACS medicinal chemistry letters2026

Discovery of Potent 1,3-Cyclobutane-Containing Dual A

Zachary G Brill, Alec H Christian, Lorena Rico, Sebastian E Schneider, Eric M Phillips, Matthew S Winston, Harini Krishnamurthy, Elisabeth T Hennessy, Umar Faruk Mansoor, Dong Xiao and 22 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Zachary G BrillMerck & Co., Inc., South San Francisco, California 94158 United States.
Alec H ChristianMerck & Co., Inc., Boston, Massachusetts 02115, United States.ORCID https://orcid.org/0000-0002-7032-230X
Lorena RicoMerck & Co., Inc., Boston, Massachusetts 02115, United States.ORCID https://orcid.org/0009-0000-4223-1294
Sebastian E SchneiderMerck & Co., Inc., Boston, Massachusetts 02115, United States.ORCID https://orcid.org/0000-0003-1233-8984
Eric M PhillipsMerck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0003-3530-8876
Matthew S WinstonMerck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0002-0228-4911
Harini KrishnamurthyMerck & Co., Inc., West Point, Pennsylvania 19486, United States.
Elisabeth T HennessyMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Umar Faruk MansoorMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Dong XiaoMerck & Co., Inc., Boston, Massachusetts 02115, United States.ORCID https://orcid.org/0000-0001-8936-0448
Jing SuMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Ping LiuMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Christopher PlummerMerck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0001-5522-1933
Anthony PalmieriMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Julia Vela RamirezMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Armetta HillMerck & Co., Inc., Boston, Massachusetts 02115, United States.
William DeweyMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Daniel TatosianMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Diane RindgenMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Oluwaseun OgunbodedeMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Nadya SmotrovMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Jennifer PiesvauxMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Paul CiaccioMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Peter FanMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Roshi AfsharMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Pierre DaublainMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Jeremy PreslandMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Karin M OtteMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Amjad AliMerck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0001-5927-0978
Jared CummingMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Sheila RanganathMerck & Co., Inc., Boston, Massachusetts 02115, United States.
Duane DeMongMerck & Co., Inc., Boston, Massachusetts 02115, United States.ORCID https://orcid.org/0009-0007-0644-2677

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor microenvironment is characterized by conditions that frequently lead to immunosuppression, allowing tumors to escape immune surveillance and potentially contributing to resistance to immuno-oncology therapeutics. A potential strategy for combination therapy with checkpoint inhibitors is to target the A

Indexed as

A2A/A2B receptor antagonistscancer treatmentcombination therapytriazoloquinazoline

Identifiers

PMID42157841
PMCPMC13181494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.