Evidence map›Paper›PMID 42157835›Full record

ArticleACS medicinal chemistry letters2026

Spirocyclohexane-Chroman-4-one Derivatives as Selectively Cytotoxic Agents in Breast Cancer Models.

Daria A Ipatova, Viktoria A Ikonnikova, Kirill D Kungurtsev, Ayrat I Kashapov, Radik R Shafikov, Victor G Kartsev, Andrey K Glushkov, Ivan N Myasnyanko, Mikhail S Baranov, Andrey A Mikhaylov and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daria A IpatovaDepartment of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.
Viktoria A IkonnikovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.
Kirill D KungurtsevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.
Ayrat I KashapovDepartment of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.
Radik R ShafikovDepartment of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.
Victor G KartsevInterBioScreen Ltd., Institutsky Prospect, 7a, Chernogolovka 142432, Russia.
Andrey K GlushkovDepartment of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.
Ivan N MyasnyankoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.
Mikhail S BaranovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.ORCID https://orcid.org/0000-0002-9339-7603
Andrey A MikhaylovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117437, Russia.ORCID https://orcid.org/0000-0001-9433-9141
Olga A DontsovaDepartment of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.
Dmitry A SkvortsovDepartment of Chemistry, Moscow State University (MSU), Leninskie Gory, Building 1/3, Moscow 119991, Russia.ORCID https://orcid.org/0000-0001-8336-8596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The design of novel small molecules with high selectivity for anticancer action remains a priority in the development of chemotherapy. A combination of the "privileged scaffold" of the chroman-4-one with rigid spirocyclic structures offers a strategy for modulating the specificity of action. A collection of 28 spirocyclohexane-chroman-4-one derivatives was screened using fluorescence cell coculture test, and compound

Indexed as

Breast cancerChroman-4-oneMCF7Selective cytotoxicitySpirocyclic compoundsStructure−activity relationship

Identifiers

PMID42157835
PMCPMC13181454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.