Evidence map›Paper›PMID 42157821›Full record

ArticleACS medicinal chemistry letters2026

Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimics.

Zhenming Yu, Wenxin Shi, Zhijie Qian, Xinning Mei, Xinhui Huang, Xi Chen, Wentao Wang, Tianyi Zhang, Xin Chen, Zhiyong Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhenming YuSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Wenxin ShiFaculty of Medical Imaging, Second Military Medical University (Naval Medical University), Shanghai 200433, China.
Zhijie QianSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Xinning MeiSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Xinhui HuangThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Xi ChenThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Wentao WangSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Tianyi ZhangSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Xin ChenSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Zhiyong LiFaculty of Medical Imaging, Second Military Medical University (Naval Medical University), Shanghai 200433, China.
Canhui ZhengThe Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China.ORCID https://orcid.org/0000-0002-3468-1620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical application of doxorubicin in cancer therapy is significantly limited by its severe cardiotoxicity, with complex mechanisms. No effective protective agents are currently available, creating an urgent clinical need. In this study, through structural optimization of ebselen, we developed a series of isoselenazolinones with improved water solubility and glutathione peroxidase (GPx)-like activity. The most promising acidic and basic derivatives,

Indexed as

Doxorubicin-Induced CardiotoxicityGlutathione peroxidase mimicsIsoselenazolinonesOxidative stressQuantum chemical calculations

Identifiers

PMID42157821
PMCPMC13181493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.