Evidence map›Paper›PMID 42157745›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Mitochondria-Targeting Moieties Based on N-Tethered Pyridinium Cations.

Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič-Raščan, Bostjan Markelc, Tim Bozic and 18 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Ivan DžajićFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.ORCID 0009-0009-7943-4031
Natalija TrunkeljFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.ORCID 0009-0008-8851-9339
Jernej RepasFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Maša KandušerFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0001-7854-0750
Lara SmrdelFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Stane PajkFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Lovro ŽibernaFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Irena Mlinarič-RaščanFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Bostjan MarkelcDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Tim BozicDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Masa OmerzelDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Tanja JesenkoDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Maja CemazarDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.ORCID 0000-0002-1418-1928
Katja KološaDepartment of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia.
Bojana ŽeguraDepartment of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia.
Miha VirantJožef Stefan Institute, Ljubljana, Slovenia.
Matic LozinšekJožef Stefan Institute, Ljubljana, Slovenia.ORCID 0000-0002-1864-4248
Hai M NguyenDepartment of Pharmacology, School of Medicine, University of California, Davis, California, USA.
Joshua A NasburgDepartment of Pharmacology, School of Medicine, University of California, Davis, California, USA.
Heike WulffDepartment of Pharmacology, School of Medicine, University of California, Davis, California, USA.ORCID 0000-0003-4437-5763
Maxime GueguinouInserm UMR1069 "Niche Nutrition Cancer and Oxydative Metabolism (N2COx)", University of Tours, Tours, France.ORCID 0000-0002-5793-2082
Valerije VrčekFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Veronica CarpaneseDepartment of Biology, University of Padova, Padova, Italy.ORCID 0009-0009-7080-4868
Ildiko SzaboDepartment of Biology, University of Padova, Padova, Italy.ORCID 0000-0002-3637-3947
Luis A PardoCity Campus, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Tihomir TomašičFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0001-5534-209X
Lucija Peterlin MašičFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0003-0624-8472
Andrej Emanuel CotmanFaculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0003-2528-396X

Funding

European Regional Development Fund OP20.05187 RI-SI-EATRISEuropean Research Council 950625Italian Association for Cancer ResearchMinistry of Higher Education, Science, and InnovationThe Slovenian Research and Innovation Agency J7-4635The Slovenian Research and Innovation Agency P1-0208The Slovenian Research and Innovation Agency P3-0003University of Ljubljana SN-ZRD/22-27/510
6 · The paper itself

Abstract

Mitochondria-targeting moieties (MTMs) are molecular fragments designed to deliver covalently tethered functional cargo to mitochondria, providing a modular strategy for chemical biology tools, imaging agents, and mitochondria-targeted therapies. Phosphonium- or nitrogen cation-based MTMs are not inert vectors and exhibit intrinsic bioactivity on mitochondrial and cellular levels to various extents. Here, we systematically evaluated a panel of N

Indexed as

Antineoplastic AgentsMitochondriaPyridinium CompoundsApoptosisCationsCell Line, TumorFluorescent DyesHumansMembrane Potential, MitochondrialMolecular StructureAntineoplastic AgentsCationsFluorescent DyesPyridinium Compoundscancercationsfluorescent probesmedicinal chemistrymitochondria

Identifiers

PMID42157745
PMCPMC13360495

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.