Evidence map›Paper›PMID 42157735›Full record

ArticlePathologica2026

Detection of NTRK gene fusions in sarcomas: a comparative study of Pan-TRK immunohistochemistry, FISH, and RNA-Based NGS.

Stefania Cocchi, Marco Gambarotti, Gabriella Gamberi, Giovanna Magagnoli, Margherita Maioli, Alessandro Parra, Enrica Sciulli, Toni Ibrahim, Alberto Righi, Stefania Benini

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stefania CocchiDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Marco GambarottiDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Gabriella GamberiDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Giovanna MagagnoliDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Margherita MaioliDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Alessandro ParraDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Enrica SciulliDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Toni IbrahimOsteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Alberto RighiDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Stefania BeniniDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fusion involving Methods: We retrospectively reviewed 92 soft tissue and bone sarcomas diagnosed at the Rizzoli Institute between 2019 and 2023, in which pan-TRK IHC was performed. 17 tumours showed positive staining and were further assessed using FISH for Results: In total, we collected data from 17 patients who tested positive for pan-TRK antibody and compared pan-TRK IHC and molecular testing for the detection of Conclusions: Pan-TRK IHC can be considered an initial screening tool to identify sarcomas potentially harbouring

Indexed as

Gene FusionSarcomaBiomarkers, TumorBone NeoplasmsHigh-Throughput Nucleotide SequencingHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMembrane GlycoproteinsReceptor, trkAReceptor, trkBReceptor, trkCRetrospective StudiesBiomarkers, TumorMembrane GlycoproteinsNTRK1 protein, humanNTRK3 protein, humanReceptor, trkAReceptor, trkBReceptor, trkCtropomyosin-related kinase-B, humanfluorescent in situ hybridisation (FISH)next-generation sequencing (NGS)pan-TRK immunohistochemistry (IHC)sarcoma

Identifiers

PMID42157735
PMCPMC13187865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.