Evidence map›Paper›PMID 42157719›Full record

ArticleJournal of chemical information and modeling2026

Emerging Insights into the Distinct Pharmacological Mechanisms of Buprenorphine.

Aràntzazu Alonso-Carrasco, Aleix Quintana-Garcia, Marc Ciruela-Jardí, Verònica Casadó-Anguera, Garett A Enten, Natàlia Llopart, Berta Carrasco-Martinez, Ning-Sheng Cai, Estefanía Moreno, Sergi Ferré and 2 more

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aràntzazu Alonso-CarrascoLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona08007, Spain.ORCID 0000-0002-1186-4117
Aleix Quintana-GarciaLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra08193, Spain.ORCID 0000-0003-4472-5129
Marc Ciruela-JardíLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona08007, Spain.ORCID 0009-0001-9920-8789
Verònica Casadó-AngueraLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona08007, Spain.
Garett A EntenIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland20892, United States.
Natàlia LlopartLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona08007, Spain.
Berta Carrasco-MartinezLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra08193, Spain.ORCID 0009-0009-2032-1470
Ning-Sheng CaiIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland20892, United States.
Estefanía MorenoLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona08007, Spain.ORCID 0000-0002-2491-5753
Sergi FerréIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland20892, United States.ORCID 0000-0002-1747-1779
Vicent CasadóLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona08007, Spain.ORCID 0000-0002-1764-3825
Leonardo PardoLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra08193, Spain.ORCID 0000-0003-1778-7420

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphine, an agonist of the μ-opioid receptor (μOR), extracted from

Indexed as

Analgesics, OpioidBuprenorphineReceptors, Opioid, muBinding SitesHumansMolecular Dynamics SimulationMorphineProtein BindingThermodynamicsAnalgesics, OpioidBuprenorphineMorphineReceptors, Opioid, mu

Identifiers

PMID42157719
PMCPMC13250898

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.