Trial reportCNS neuroscience & therapeutics2026
Exercise Effect on Cerebral Artery Hemodynamic and Morphology in Stroke Patients: A Randomized Trial.
Trial report in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05706168 (A Study to Investigate the Effects of Aerobic Exercise Training), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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A Study to Investigate the Effects of Aerobic Exercise Training (AET) on the Large Intracranial and Extracranial Cerebral Arteries and the Cognitive and Motor Functions in Post Stroke Patients.
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Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimsStroke is a leading cause of death and disability worldwide and occurs primarily due to impaired cerebrovascular health. Aerobic exercise training (AET) has the potential to improve deconditioned cerebrovascular status in post-stroke patients, but its utility remains underexplored. This study assessed the effects of AET on cerebral artery morphology and hemodynamics in post-stroke patients using advanced ultrasonography techniques.
methodsA randomized controlled trial (RCT) involving post-stroke patients randomly assigned to either a 12-week, high-intensity supervised cycling AET program (3 sessions per week, 30 min per session) or stretching (control) program was conducted. Duplex carotid ultrasound novel applications assessed pre- and post-intervention morphological features (carotid intima-media thickness (CIMT), arterial stiffness, and 3D features) and hemodynamics (resistive index (RI), pulsatility index (PI)). Transcranial color-coded Doppler (TCCD) assessed middle cerebral artery (MCA) hemodynamics.
resultsA total of 42 post-stroke patients, mean age (64.4 ± 7.6 years) were enrolled (cycling AET, n = 21 and stretching, n = 21). Mixed design ANOVA revealed significant time*exercise group interactions for CIMT, compliance, and distensibility (all p < 0.05). Cycling AET significantly improved CIMT (between group mean difference (MD) = -0.04 mm, p < 0.043), distensibility (MD = 0.003 (1/kPa)), compliance (MD = 0.11 mm/kPa, all p < 0.001). Modest within-group improvements were observed in internal carotid artery, RI (MD = -0.05, p < 0.001), and PI (MD = -0.2, p < 0.001). No significant changes observed in MCA hemodynamics.
conclusionHigh-intensity cycling AET improved cerebral arteries' morphology and modestly enhanced extracranial hemodynamics in post-stroke patients, without affecting MCA hemodynamics. Further studies are recommended to explore long-term vascular benefits of AET.
trial registrationClinicalTrials.gov identifier: NCT05706168.
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