Evidence map›Paper›PMID 42157595›Full record

ArticleTransfusion2026

A case-control study of blood group antigen expression in Babesia microti infected patients in the United States.

Ryan P Jajosky, Matthew Adjodha, Emma L Berdan, Craig D Tauscher, Jillian D Rupprecht, Nicole R Dodge, Sheila K Moldenhauer, Bobbi S Pritt, Kristen N Ruby, Justin E Juskewitch

Abstract read
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In one paragraph

Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ryan P JajoskyJoint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-8458-7635
Matthew AdjodhaDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Emma L BerdanHarvard Chan Bioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard Medical School, Boston, Massachusetts, USA.
Craig D TauscherDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Jillian D RupprechtDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Nicole R DodgeDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Sheila K MoldenhauerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Bobbi S PrittDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Kristen N RubyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0001-7089-1046
Justin E JuskewitchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Funding

Etiology of naturally-occurring anti-ABO antibodiesK08HL171877 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Ryan P Jajosky · 2024 to 2026
$505k
AABBMayo ClinicNHLBI NIH HHS K08 HL171877NIH HHS K08HL171877-02
6 · The paper itself

Abstract

backgroundBabesia and Plasmodium are intraerythrocytic parasites that cause babesiosis and malaria, respectively. Significant associations between human blood group antigens and malaria are known; however, few studies have examined the relationship between blood group antigens and babesiosis. STUDY DESIGN AND

methodsFrom June to August 2025, 100 Babesia polymerase chain reaction (PCR)- and 100 B. microti PCR+ human patient samples tested at a national reference laboratory underwent ABO and D phenotyping and red blood cell (RBC) genotyping of 37 antigens.

resultsThe predicted phenotype of S-s+ was found in 32% and 50% of Babesia- and B. microti+ patients, respectively (χ DISCUSSION: Because multiple testing corrections were not applied to the statistical analyses, the S/s predicted phenotype results must be viewed as hypothesis-generating. This may be the first study to link B. microti infection to human RBC S/s antigens, which are known to impact B. divergens and P. falciparum. Additional studies are needed to understand the impact of the babesiosis patient's blood type on B. microti infection and whether the transfusion of RBCs expressing specific antigens can impact the disease.

Indexed as

Babesia microtiBabesiosisBlood Group AntigensAdultCase-Control StudiesErythrocytesFemaleHumansMaleMiddle AgedUnited StatesBlood Group AntigensBabesia microtibabesiosisblood group systemserythrocyte antigensglycobiologyglycophorin BhematologyMNS blood groupparasitologyRBC genotypingsialic acid

Identifiers

PMID42157595
PMCPMC13452591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.