Evidence map›Paper›PMID 42157522›Full record

ArticleAndrology2026

Congenital Penile Curvature Is Associated With Larger Penile Dimensions: A Matched Case-Control Study.

Celeste Manfredi, Simone Tammaro, Lorenzo Spirito, Lorenzo Romano, Marco Stizzo, Marco Terribile, Carmelo Quattrone, Francesco Bottone, Savio Domenico Pandolfo, Luigi Napolitano and 11 more

Abstract read
In one paragraph

Article in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Celeste ManfrediUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Simone TammaroUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Lorenzo SpiritoUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Lorenzo RomanoUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Marco StizzoUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Marco TerribileUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Carmelo QuattroneUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Francesco BottoneUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Savio Domenico PandolfoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Luigi NapolitanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Biagio BaroneDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Riccardo LombardoSant 'Andrea Hospital, Sapienza University, Rome, Italy.
Marco FalconeUrology Department, Città della Salute e della Scienza di Torino, Torino, Italy.
Luca BoeriDepartment of Urology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Marco CapeceDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Felice CrocettoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Ferdinando FuscoUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Javier Romero OteroDepartment of Urology, Hospital Universitario HM Sanchinarro, Instituto de Investigación Sanitaria HM Hospitales, ROC Clinic, Madrid, Spain.
Riccardo AutorinoDepartment of Urology, Rush University Medical Center, Chicago, Illinois, USA.
Marco De SioUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Davide ArcanioloUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical observation suggests that men with congenital penile curvature (CPC) often appear to have larger penile dimensions, yet this association has never been objectively investigated. Establishing whether CPC is linked to increased penile size could refine its morphometric characterization, improve preoperative counseling, and inform normative penile measurement references.

objectivesTo determine whether men with CPC have greater stretched penile length (SPL) and mid-shaft penile circumference compared with age-, height-, and BMI-matched controls. MATERIALS AND

methodsThis single-center, retrospective, matched case-control study was conducted at a tertiary referral andrology center. Consecutive men with lifelong penile curvature ≥ 30°, without plaques, fibrosis, or trauma, were identified through standardized assessment using pharmacologically induced erection or self-photography (Kelami method). Each case was individually matched (1:2) with controls for age (±2 years), height (±3 cm), and BMI (±2 kg/m

resultsFifty men with CPC and 100 matched controls were analyzed. Matching achieved an adequate balance for anthropometric parameters (all standardized mean differences < 0.10). Men with CPC had significantly greater SPL (mean within-set difference 1.82 cm; 95% CI 1.48-2.16; p < 0.001) and mid-shaft circumference (0.72 cm; 95% CI 0.48-0.96; p < 0.001). In exploratory subgroup analyses, length differences appeared greater in men with more severe curvature, although these findings should be interpreted cautiously.

conclusionMen with CPC showed significantly greater penile dimensions than matched controls, supporting the hypothesis that CPC may be associated with a distinct morphometric pattern and suggesting potential relevance for surgical counseling, measurement standards, and future research.

Indexed as

Penile DiseasesPenisAdultCase-Control StudiesHumansMaleMiddle AgedOrgan SizeRetrospective Studiescongenital penile curvaturepenile circumferencepenile developmentpenile lengthpenile morphologypenile size

Identifiers

PMID42157522
PMCPMC13432560

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