Evidence map›Paper›PMID 42157433›Full record

ArticleAdvanced healthcare materials2026

Multidimensional Cellular Micro-Compartments to Model Invasive Lobular Carcinoma Dormancy.

Xilal Y Rima, Sarmila Majumder, Divya S Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon-Ralls, Chiranth K Nagaraj, Mangesh D Hade and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Xilal Y RimaWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-5633-5887
Sarmila MajumderDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Divya S PatelWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Chunyu HuWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Hong LiWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Xin HuangWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Kim Truc NguyenWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Jacob Doon-RallsWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Chiranth K NagarajWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
Mangesh D HadeCenter for Clinical and Translational Research, Nationwide Children's Hospital, Columbus, Ohio, USA.
Setty M MagañaCenter for Clinical and Translational Research, Nationwide Children's Hospital, Columbus, Ohio, USA.
Eswar ShankarDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Xiaoli ZhangDepartment of Biomedical Informatics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Daniel G StoverDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Bhuvaneswari RamaswamyDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Eduardo ReáteguiWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-8271-8205

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Multi-parametric Integrated Molecular Detection of SARS-CoV-2 from Biofluids by Adapting Single Extracellular Vesicle Characterization TechnologiesU18TR003807 · NCATS · OHIO STATE UNIVERSITY · PI LEE, INYOUL, LEE, LY JAMES · 2021 to 2022
$1.8M
Postdoctoral Training in Cardiometabolic ScienceT32HL149637 · NHLBI · OHIO STATE UNIVERSITY · PI HSUEH, WILLA A, SMITH, SAKIMA AHMAD · 2020 to 2024
$1.5M
Burroughs Wellcome Fund 1285320NCATS NIH HHS U18 TR003807NCATS NIH HHS U18TR003807NCATS NIH HHS UG3/UH3TR002884NCI NIH HHS P30 CA016058NCI NIH HHS P30CA016058NHLBI NIH HHS T32 HL149637NHLBI NIH HHS T32HL149637President's Research Excellence Program at The Ohio State UniversitySigma Xi Grants in Aid of ResearchTranslational Therapeutics Seed Award at The Ohio State Comprehensive Cancer CenterU.S. National Institutes of HealthW.K. Kellogg Foundation Postdoctoral Recruitment and Onboarding Supplement
6 · The paper itself

Abstract

Invasive lobular carcinoma (ILC) accounts for 10-15% of breast cancers. Despite favorable responses to anti-estrogen therapy, the dissemination of cancer cells and resistance to therapies are significant risks for patients with ILC. Late recurrences are prevalent in ILC, suggesting that disseminated tumor cell (DTC) dormancy may be a mechanism preceding their late overt growth into metastatic lesions. Herein, we investigated the relationship between anti-estrogen resistance and dormancy through multidimensional, micro-compartmentalized in vitro models. The bioengineered platforms recapitulated the morphological characteristics of ILC and highlighted its distinction from invasive ductal carcinoma (IDC). Inducing a reversible dormant phenotype revealed epigenetic changes and enhanced chemical and mechanical sensing of anti-estrogen-resistant ILC cells to the substrate surface, with p27

Indexed as

Breast NeoplasmsCarcinoma, LobularCell Line, TumorFemaleHumansNeoplasm Invasivenesscancer dormancyinvasive lobular carcinomamicrofluidicsmicropatterningphotopolymerization

Identifiers

PMID42157433
PMCPMC13495827

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.