Evidence map›Paper›PMID 42157406›Full record

ArticleMolecular plant pathology2026

ZmNPSN13 Potentiates Maize Rough Dwarf Disease Upon Recruitment by the RBSDV P7-1 Effector.

Suining Deng, Yixiao Qin, Baoshen Liu, Siqi Jiang, Tao Zhong, Qingcai Liu, Jianju Liu, Yuanliang Liu, Manman Li, Yanmei Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Suining DengState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Yixiao QinState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Baoshen LiuCollege of Agronomy/State Key Laboratory of Crop Biology, Shandong Agricultural University, Taian, China.
Siqi JiangState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Tao ZhongState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Qingcai LiuState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.ORCID 0009-0005-7495-7715
Jianju LiuState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Yuanliang LiuState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Manman LiState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Yanmei LiState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Mingzhu YanState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Qian LiState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.
Mingliang XuState Key Laboratory of Maize Bio-Breeding/College of Agronomy and Biotechnology/National Maize Improvement Center, China Agricultural University, Beijing, China.ORCID 0000-0003-2328-474X

Funding

Biological Breeding-Major Projects 2023ZD04070Breeding Research and Development Program NK20230702
6 · The paper itself

Abstract

Maize rough dwarf disease (MRDD), caused by fijiviruses, poses a major threat to global maize production, with rice black-streaked dwarf virus (RBSDV) being the predominant pathogen in Asia. The viral effector P7-1 initiates MRDD by hijacking the host susceptibility factor ZmGDIα, while its reduced affinity for the helitron-inserted variant ZmGDIα-hel underlies recessive resistance. Here, we identified the Qb-SNARE protein ZmNPSN13 as a novel host target of P7-1. ZmNPSN13 functions as a central hub, interacting with both ZmGDIα and the gibberellin-inactivating enzyme ZmGA2ox7.3. During infection, P7-1 recruits these host components into a pathogenic complex that disrupts phytohormone homeostasis, thereby driving MRDD development. Notably, knockout of ZmNPSN13 restored hormonal balance and enhanced viral resistance comparable to that achieved by replacing ZmGDIα with ZmGDIα-hel. Our work uncovers a mechanism by which a virus exploits SNARE-mediated vesicle trafficking to subvert host immunity, establishing ZmNPSN13 as a promising target for engineering MRDD-resistant maize cultivars.

Indexed as

Plant DiseasesPlant ProteinsPlant VirusesSNARE ProteinsViral ProteinsZea maysDisease ResistanceHost-Pathogen InteractionsPlant Growth RegulatorsPlant Growth RegulatorsPlant ProteinsSNARE ProteinsViral Proteinsmaize rough dwarf diseasephytohormoneplant SNARE proteinZmGDIα‐hel

Identifiers

PMID42157406
PMCPMC13581069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.