Evidence map›Paper›PMID 42157342›Full record

ArticleJournal of animal science and biotechnology2026

Microbiota transplantation and multi-omics profiling integration unveil the mechanism of Alistipes communis-driven abdominal fat deposition in chickens.

Yang Jing, Shuai Liu, Li Leng, Jiarui He, Tianqi Wang, Yunnan Guan, Zhiyong Su, Wenpeng Zhang, Yumao Li, Peng Luan and 3 more

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In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yang Jing *College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Shuai Liu *College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Li LengCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Jiarui HeCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Tianqi WangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Yunnan GuanCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Zhiyong SuCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Wenpeng ZhangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Yumao LiCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Peng LuanCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Bohan ChengCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Ning WangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Hui LiCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China. lihui@neau.edu.cn.

Funding

National Key Research and Development Program of China No. 2022YFF1000201National Major Agricultural Science and Technology Project No. NK20221001National Natural Science Foundation of China No. 32272863The earmarked fund for CARS-41 No. CARS-41
6 · The paper itself

Abstract

backgroundEmerging evidence highlights strong correlations between the cecal microbiome and abdominal fat deposition (AFD) in chickens. However, the specific microbial species driving this process remain unclear. This study aims to identify the key microbe and elucidate its underlying mechanism in regulating chicken AFD.

resultsFirst, cecal microbiota transplantation confirmed a causal relationship between the cecal microbiota and AFD. Subsequently, metagenomic and metatranscriptomic integrations identified Alistipes communis as a key microbe implicated in AFD. Finally, in vivo gavage integrated with multi-omics revealed that A. communis enhances AFD by disrupting host tryptophan and histidine metabolism. This was evidenced by the elevated concentrations of amino acid metabolism-related metabolites, including L-phosphoarginine and spermine in the cecum.

conclusionsThis study provides direct evidence that the cecal microbiome serves as a key driver in chicken AFD and identifies A. communis as a critical AFD regulator, offering valuable insights into the gut microbiome's role in host obesity.

Indexed as

Abdominal fat depositionAlistipes communisCecal microbiota transplantationChickenMulti-omicsTryptophan and histidine metabolism

Identifiers

PMID42157342
PMCPMC13188826

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