Evidence map›Paper›PMID 42157286›Full record

ArticleJournal of nanobiotechnology2026

Impeding glial scarring hyperplasia and activating axon neogenesis via immunomodulatory microneedle patch for spinal cord repair.

Tao Zhou, Yajing Lin, Ying Wang, Lin Lin, Jingtong Li, Ning Tang, Yingji Mao, Pinghui Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tao Zhou *Department of Orthopedics, Anhui Province Key Laboratory of Tissue Transplantation, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China.
Yajing Lin *Department of Orthopedics, Anhui Province Key Laboratory of Tissue Transplantation, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China.
Ying Wang *Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, School of Life Sciences, Bengbu Medical University, Bengbu, 233030, China.
Lin LinDepartment of Orthopedics, Anhui Province Key Laboratory of Tissue Transplantation, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China.
Jingtong LiDepartment of Orthopedics, Anhui Province Key Laboratory of Tissue Transplantation, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China.
Ning TangDepartment of Orthopedics, Anhui Province Key Laboratory of Tissue Transplantation, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China.
Yingji MaoAnhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, School of Life Sciences, Bengbu Medical University, Bengbu, 233030, China. myj123@bbmu.edu.cn.
Pinghui ZhouDepartment of Orthopedics, Anhui Province Key Laboratory of Tissue Transplantation, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China. phzhou@bbmu.edu.cn.

Funding

Anhui Provincial Clinical Medical Research Transformation Project 202304295107020077Key Project of Health Commission of Anhui Province AHWJ2024Aa10054Longhu Talent Project of Bengbu Medical University LH250303003Natural Science Foundation of Anhui Province 2308085MH262Natural Science Research Project of the Anhui Educational Committee 2022AH020086Opening Project of Anhui Province Key Laboratory of Tissue Transplantation in Bengbu Medical College AHTT2022A001Opening Project of Anhui Province Key Laboratory of Tissue Transplantation in Bengbu Medical College AHTT2024B001
6 · The paper itself

Abstract

Immune dysregulation and scar tissue formation following traumatic spinal cord injury (SCI) result in the generation of a microenvironment that significantly inhibits nerve regeneration and functional recovery. Continuous drug delivery across the dura, with minimal damage, and modulation of this inhibitory microenvironment pose substantial challenges in SCI treatment. This study fabricated a pH-responsive immunomodulatory microneedle (MN) patch by incorporating zeolitic imidazolate framework-8 (Zif-8) nanoparticles loaded with chondroitinase ABC (ChABC) into a gelatin methacrylate (GelMA) hydrogel (Z@C-MN). As the patch progressively degraded, this system continuously released Zn

Indexed as

AxonsCicatrixSpinal Cord InjuriesSpinal Cord RegenerationAnimalsChondroitin ABC LyaseFemaleGelatinHydrogelsHydrogen-Ion ConcentrationMicroneedle Drug DeliveryNanoparticlesNerve RegenerationNeural Stem CellsRatsRats, Sprague-DawleyChondroitin ABC LyaseGelatinHydrogelsAxon regenerationChondroitinase ABCImmune regulationMicroneedle patchZeolitic imidazolate framework-8

Identifiers

PMID42157286
PMCPMC13359562

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.