ArticleBiology direct2026
The Wnt/StarD7 axis protects retinal ganglion cells from glutamate excitotoxicity by inhibiting ferroptosis.
Article in Biology direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGlutamate (Glu) accumulation-induced excitotoxicity is a major cause of retinal ganglion cell (RGC) death in glaucoma, and the role of ferroptosis, a novel form of cell death, is critical in this process. The aim of this study was to investigate the function and regulatory mechanisms of the lipid transport protein StarD7 in RGC ferroptosis.
methodsAn N-methyl-D-aspartate (NMDA)-induced retinal excitotoxicity mouse model and a Glu-induced RGC cell model were constructed for experimental investigation. RT‒qPCR and Western blotting were used to assess the expression of related genes and proteins, HE staining was used to assess pathological retinal damage, and kits were used to evaluate ferroptosis-related indicators.
resultsFerroptosis was involved in NMDA-induced RGC damage in glaucoma mice. StarD7 expression was upregulated in glaucoma, and overexpression of StarD7 decreased the levels of total iron, Fe
conclusionThe Wnt/β-catenin signaling pathway inhibits Glu-induced RGC ferroptosis by upregulating StarD7 expression, revealing the potential neuroprotective role of StarD7 in glaucoma treatment and providing a scientific basis for the development of new therapeutic strategies. CLINICAL TRIAL NUMBER: Not applicable.
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