Evidence map›Paper›PMID 42157203›Full record

ArticleJournal of nanobiotechnology2026

Rhein-Mn coordination nanomedicine for peritoneal metastatic colorectal cancer: synergistic mitochondrial targeting, immunogenic cell death, and reverses immunosuppression.

Yingfei Wen, Miaojuan Qiu, Xinyi Deng, Yiran Wang, Xiaodie Zeng, Binbin Li, Shangbo Zhou, Takeshi Yamakawa, Peng Liu, Shiqiang Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yingfei Wen *Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Miaojuan Qiu *Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Xinyi DengScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Yiran WangScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Xiaodie ZengSchool of Materials Science and EngineeringCenter for Functional Biomaterials, Key Laboratory for Polymeric Composite and Functional Materials of the Ministry of Education, Sun Yat-sen University, Guangzhou, 510275, P.R. China.
Binbin LiGastrointestinal SurgeryDigestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Shangbo ZhouGastrointestinal SurgeryDigestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Takeshi YamakawaScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Peng LiuGastrointestinal SurgeryDigestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Shiqiang ZhangScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Jingqi ChenScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Yiye ChiBachelor Program of Bioinformatics, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, P. R. China.
Feng ChenScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China. chenf293@mail.sysu.edu.cn.
Zhiyong WangSchool of Materials Science and EngineeringCenter for Functional Biomaterials, Key Laboratory for Polymeric Composite and Functional Materials of the Ministry of Education, Sun Yat-sen University, Guangzhou, 510275, P.R. China. wangzhiy3@mail.sysu.edu.cn.
Jing ZhaoScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, P. R. China. zhaoj265@mail.sysu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515010690 and 2025A1515011060Guangdong Medical Science and Technology Research Fund Project of China A2025284National Natural Science Foundation of China 82573410Shenzhen Medical Research Fund D2301010 and D2503009Shenzhen Science and Technology Program JCYJ20230807110708018Shenzhen Science and Technology Program RCYX20231211090346060 and JCYJ20240813150403005
6 · The paper itself

Abstract

The treatment of peritoneal metastatic colorectal cancer (pmCRC) remains highly challenging because current therapies fail to eradicate minimal residual disease and effectively overcome the immunosuppressive tumor microenvironment (TME). These limitations promote immune evasion and uncontrolled peritoneal dissemination, resulting in a poor prognosis. To address these challenges, we developed a bovine serum albumin-encapsulated rhein-manganese nanomedicine (BRM) using a precisely controlled albumin-assisted assembly strategy. BRM exhibits a uniform spherical morphology, pH-responsive degradation, and markedly improved bioavailability, enabling efficient systemic delivery. Following intraperitoneal administration, BRM selectively accumulates at peritoneal tumor sites in murine pmCRC models through receptor-mediated endocytosis. After cellular uptake, BRM escapes endo/lysosomal compartments and releases its bioactive components intracellularly. The synergistic interaction between rhein and Mn

Indexed as

AnthraquinonesColorectal NeoplasmsManganeseMitochondriaNanomedicinePeritoneal NeoplasmsAnimalsAntineoplastic AgentsApoptosisCell Line, TumorFemaleHumansImmunogenic Cell DeathMiceMice, Inbred BALB CReactive Oxygen SpeciesAnthraquinonesAntineoplastic AgentsManganeseReactive Oxygen SpeciesrheinSerum Albumin, BovineColorectal CancerImmunogenic Cell DeathImmunotherapyManganeseRhein

Identifiers

PMID42157203
PMCPMC13366722

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.