Evidence map›Paper›PMID 42157131›Full record

ArticleBMC infectious diseases2026

mNGS and IL-5: potential early diagnostic clues for clonorchiasis before eosinophil rise - a case report.

Tongtong Ji, Ran Cheng, Ming Lu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tongtong Ji *Department of Infectious Diseases, Peking University Third Hospital, Beijing, People's Republic of China.
Ran Cheng *Department of Infectious Diseases, Peking University Third Hospital, Beijing, People's Republic of China.
Ming LuDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, People's Republic of China. luming197954@163.com.

Funding

National Key R&D Program of China 2022YFC2303203-01Specialized Research Fund for Pathogenic Metagenomics of the Bacterial Infection and Drug Resistance Prevention of the Chinese Medical Association Z-2017-24-2202
6 · The paper itself

Abstract

Clonorchiasis, caused by Clonorchis sinensis, often evades early diagnosis in non-endemic regions due to its nonspecific presentation and the delayed appearance of eosinophilia. We report an informative case of a 56-year-old male with acute fever, abdominal pain, and hepatitis, where conventional diagnostics and initial antimicrobial therapy failed. In this case, metagenomic next-generation sequencing (mNGS) of blood identified C. sinensis-specific reads, and cytokine profiling revealed a marked elevation in interleukin-5 (IL-5) before the onset of peripheral eosinophilia. Targeted treatment with praziquantel led to rapid clinical resolution. This case suggests the potential of integrating mNGS and IL-5 monitoring as early diagnostic tools for clonorchiasis, which can allow for intervention prior to classical biomarker emergence.

Indexed as

ClonorchiasisClonorchis sinensisEosinophilsInterleukin-5AnimalsAnthelminticsEarly DiagnosisEosinophiliaHigh-Throughput Nucleotide SequencingHumansMaleMetagenomicsMiddle AgedPraziquantelAnthelminticsIL5 protein, humanInterleukin-5PraziquantelCase reportClonorchis sinensisEarly diagnosisEosinophiliaInterleukin-5 (IL-5)Metagenomic next-generation sequencing (mNGS)

Identifiers

PMID42157131
PMCPMC13366795

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.