ArticleBMC medical imaging2026
Enhancing mixed solid and cystic breast lesions diagnosis: a simplified scoring system integrating ultrasound features and clinical factors.
Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe American College of Radiology Breast Imaging Reporting and Data System (ACR BI-RADS) 6th Edition's updated definition of mixed solid and cystic breast lesions (MSCBLs) reflects the diagnostic challenges in assessing these lesions. This study aimed to develop and validate a scoring system based on ultrasound (US) features and clinical factors to differentiate benign from malignant MSCBLs.
methodsThis retrospective multicenter study included 499 MSCBLs from three medical centers, which were divided into a training cohort (n = 396, 79.4%) and an external validation cohort (n = 103, 20.6%). Ultrasound features and clinical characteristics were analyzed. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of malignancy, on the basis of which a nomogram was constructed. This nomogram was subsequently simplified into a practical scoring system. The performance of the scoring system was validated in the independent external cohort. Furthermore, its added diagnostic value was assessed across radiologists with different levels of experience.
resultsMultivariate logistic analysis identified age, lesion type, shape, vascularity, and lesion size as independent predictors of malignancy. The simplified scoring system demonstrated high diagnostic efficacy in the training cohort (area under the curve, AUC = 0.853, 95% CI: 0.813-0.892), with internal validation using bootstrap resampling confirming robust performance (optimism-corrected AUC = 0.834). In the external validation cohort, the scoring system demonstrated good diagnostic performance (AUC = 0.801, 95% CI: 0.710-0.893) and high interobserver agreement (weighted κ=0.78, 95% CI: 0.72-0.84). It also improved diagnostic performance for junior and intermediate radiologists, improving AUC from 0.66 to 0.74 for junior radiologists (p < 0.001) and increasing specificity for intermediate radiologists.
conclusionThe MSCBLs scoring system provides a reliable tool for risk stratification, enhancing the diagnostic performance of junior radiologists and ensuring high interobserver consistency, while serving as a valuable complement to existing risk stratification systems.
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