Evidence map›Paper›PMID 42157066›Full record

ArticleParticle and fibre toxicology2026

Cu(OH)

Zhihua Ren, Yixue Cai, Yonghui Duan, Xiao Wang, Jiafei Sun, Danqin Ren, Jiefeng Liang, Tingting Ku, Xia Ning, Nan Sang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhihua RenShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China.
Yixue CaiShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China.
Yonghui DuanShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China.
Xiao WangShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China.
Jiafei SunShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China.
Danqin RenShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China.
Jiefeng LiangShandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao, 266237, China.
Tingting KuShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China.
Xia NingShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China.
Nan SangShanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan, 030006, China. sangnan@sxu.edu.cn.

Funding

National Natural Science Foundation of China 22306115National Natural Science Foundation of China 22376130National Natural Science Foundation of China U25A20587
6 · The paper itself

Abstract

backgroundNanopesticides have been progressively incorporated into contemporary agricultural systems owing to their distinctive physicochemical characteristics and superior pest management capabilities. Given their environmental persistence and propensity for bioaccumulation, nanopesticides are increasingly recognized as emerging cardiovascular toxicants, thus warranting systematic investigation of their exposure-associated cardiotoxic effects.

methodsIn the present study, the impact of Cu(OH)

resultsIt was demonstrated that prolonged exposure to this copper-based nanopesticide resulted in significant deterioration of ventricular systolic and diastolic function, induction of ventricular chamber remodeling, disturbance of hemodynamic stability, and dysregulation of cardiac substructural gene expression, collectively mirroring the characteristic phenotypic manifestations and underlying molecular hallmarks of clinical heart failure. The dysregulation of Cu(OH)

conclusionThe present findings provide new insights into the cardiovascular hazards posed by Cu(OH)

Indexed as

CardiotoxicityCopperHydroxidesNanoparticlesPesticidesAnimalsbeta CateninMaleMiceMice, Inbred C57BLMicroRNAsToxicity TestsVentricular RemodelingWnt Signaling Pathwaybeta CateninCoppercopper hydroxideHydroxidesMicroRNAsPesticidesCardiotoxicityCu(OH)2 nanopesticideHeart failuremiRNA regulationWnt/β-catenin signaling pathway

Identifiers

PMID42157066
PMCPMC13202851

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.