Evidence map›Paper›PMID 42157022›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Mixtures of key components of the external exposome in association with MRI biomarkers of brain structure: Multi-Ethnic Study of Atherosclerosis.

Cameron J Reimer, Tara E Jenson, Yorghos Tripodis, Koichiro Shiba, Peter James, Kipruto Kirwa, Susan R Heckbert, Jana A Hirsch, Lilah Besser, Timothy Hughes and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cameron J ReimerDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2058-0538
Tara E JensonDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Yorghos TripodisDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Koichiro ShibaDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Peter JamesDepartment of Public Health Sciences, Davis School of Medicine, University of California, Davis, California, USA.
Kipruto KirwaDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Jana A HirschDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.
Lilah BesserDepartment of Neurology, Comprehensive Center for Brain Health, University of Miami Miller School of Medicine, Boca Raton, Florida, USA.
Timothy HughesSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Joel D KaufmanDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Brent A CoullDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Marcia Pescador JimenezDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

Funding

Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESAR01HL127659 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2015 to 2018
$7.4M
Longitudinal Neighborhood Determinants of ADRD Progression within a Multi-Site CohortR01AG072634 · NIA · DREXEL UNIVERSITY · PI Jana Ariel Hirsch · 2021 to 2026
$6.1M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Neighborhoods and CVD Risk in a Multiethnic Cohort (RMI)R01HL071759 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA · 2003 to 2013
$4.8M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4M
Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular HealthR01HL150119 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAMES, PETER · 2020 to 2024
$3.9M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8M
Characterizing health impacts of built environment features using complex dataR01HL131610 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANCHEZ, BRISA N · 2017 to 2021
$3.6M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00007 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BERTONI, ALAIN GERALD · 2020 to 2025
$3.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00002 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN J · 2020 to 2025
$3.4M
Commonwealth Universal Research EnhancementNational Institute on Aging (NIA) R00AG066949National Institute on Aging (NIA) R01AG087199NCATS NIH HHS UL1-TR-000040NCATS NIH HHS UL1-TR-001079NCATS NIH HHS UL1-TR-001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS R01 HL071759NHLBI NIH HHS R01 HL127659NHLBI NIH HHS R01 HL131610NHLBI NIH HHS R01 HL150119NIAAA NIH HHS R01 AA028552NIAAA NIH HHS R01AA028552NIA NIH HHS R00 AG066949NIA NIH HHS R01 AG049970NIA NIH HHS R01AG049970NIA NIH HHS R01AG049970-04S1NIA NIH HHS R01 AG072634NIA NIH HHS R01AG072634NIA NIH HHS R01 AG087199NIEHS NIH HHS 75N98025D00022NIEHS NIH HHS 75N98025D00024NIEHS NIH HHS 75N98025D00025NIEHS NIH HHS 75N98025D00026NIEHS NIH HHS 75N98025D00027NIEHS NIH HHS 75N98025D00028NINDS NIH HHS R01 NS139186NINDS NIH HHS R01NS139186Pennsylvania Department of Health - 2015 Formula award 4100072543
6 · The paper itself

Abstract

introductionThere is a critical need to identify risk factors of Alzheimer's disease and related dementias (ADRD).

methodsWe included 1227 participants (mean age [standard deviation]: 74.1 [7.9] years) from the Multi-Ethnic Study of Atherosclerosis with brain MRI scans. We investigated joint associations of 13 natural, social, and built-environment exposures with gray matter volume (GMV) (n = 1219), white matter fractional anisotropy (WM FA) (n = 1102), and white matter hyperintensity volume (n = 1210) using weighted quantile sum regression.

resultsA one-decile increase in all harmful exposures was associated with lower GMV and WM FA; however, associations were null when adjusting for study site. DISCUSSION: Examining the impact of many environmental factors simultaneously may provide insight into important modifiable risk factors for ADRD, capturing concomitant exposures as they are experienced.

Indexed as

AtherosclerosisBrainEnvironmental ExposureMagnetic Resonance ImagingAgedAged, 80 and overBiomarkersEthnicityFemaleGray MatterHumansMaleRisk FactorsWhite MatterBiomarkersADRDbrain magnetic resonance imaging (MRI) biomarkersenvironmental exposureexposomemixture modelsweighted quantile sumWQS

Identifiers

PMID42157022
PMCPMC13580756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.