Evidence map›Paper›PMID 42157013›Full record

ArticleCommunications medicine2026

Sex disparities in young adults aged 20-40 with acute coronary syndrome.

Nawsherwan, Yang Hu, Xiaohan Chen, Wang Bin, Zhang Le, Mangmang Sang, Lin Jiyi, Shuangjie Huang, Sicheng Li, Li Xinli and 4 more

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Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nawsherwan *Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Centre for Cardiovascular Diseases, Xiamen, China.ORCID http://orcid.org/0000-0002-9131-1511
Yang Hu *National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
Xiaohan ChenNational Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
Wang BinXiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Centre for Cardiovascular Diseases, Xiamen, China.
Zhang LeXiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Centre for Cardiovascular Diseases, Xiamen, China.
Mangmang SangXiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Centre for Cardiovascular Diseases, Xiamen, China.
Lin JiyiXiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Centre for Cardiovascular Diseases, Xiamen, China.
Shuangjie HuangNational Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
Sicheng LiXiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Centre for Cardiovascular Diseases, Xiamen, China.ORCID http://orcid.org/0000-0003-1174-3670
Li XinliDepartment of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yong HuoDepartment of Cardiology, Peking University First Hospital, Beijing, China. huoyong@263.net.cn.
Junbo GeDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China. ge.junbo@zs-hospital.sh.cn.
Weifen ZhuangNational Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China. wfzhuang@xmu.edu.cn.
Wang YanXiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Centre for Cardiovascular Diseases, Xiamen, China. wy@medmail.com.cn.ORCID http://orcid.org/0000-0001-9976-848X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex disparities in young adults aged 20-40 with acute coronary syndrome (ACS) are rarely known in China. We aimed to explore these sex-based differences, using a nationwide, population-based database.

methodsClinical data of patients with ACS (n = 89,772) registered in the Chinese Cardiovascular Association (CCA) Database-Chest Pain Centre were analyzed, including ST-elevation myocardial infarction (STEMI, 57.7%), non-ST-elevation myocardial infarction (NSTEMI, 20.7%), and unstable angina (UA, 21.5%) across males (94.0%) and females (6.0%).

resultsYoung males show a significantly higher rate of diagnostic assessment (P < 0.05) and receive approximately a 2-fold higher treatment rate than females. Young males observe a higher risk (adjusted odds ratio [aOR] 2.74, 95%CI: 2.40, 3.14) of STEMI than females. Young males aged below 24 years show a 2-fold higher in-hospital mortality (IHM) than females. Young females show a higher risk (aOR 3.23, 95%CI: 2.84, 3.67) of UA compared with males. Hypertension is associated with a higher risk of NSTEMI and UA in young males. Young females and modifiable risk factors show a positive interaction effect on the risk of STEMI and NSTEMI, whereas young males and modifiable risk factors show a positive interaction effect on the risk of UA.

conclusionsYoung males with ACS show higher access to medical care and a higher risk of STEMI, while young females have a higher risk of UA. Furthermore, males below 24 years have higher IHM compared to age-matched females. These disparities underscore the need for sex-specific interventions to reduce ACS incidence and improve early outcomes in young patients.

Identifiers

PMID42157013
PMCPMC13662208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.