ArticleNature medicine2026
A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism.
Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Longitudinal Cognitive Function in Progressive Supranuclear Palsy-A Review of the Evidence for Progression.Movement disorders clinical practice · 2026Review
- Distinct alpha-synuclein seeding in post-mortem skin of Lewy body disease and multiple system atrophy.Acta neuropathologica · 2026Article
- Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease".Annals of neurology · 2026Article
- Deciphering Freezing of Gait: What Neuropathology Reveals About an Episodic Phenomenon.The European journal of neuroscience · 2026Review
- From clinical phenotypes to molecular precision: multimodal biomarkers for progressive supranuclear palsy.Frontiers in neuroscience · 2026Review
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Differential diagnosis of neurodegenerative parkinsonian syndromes is complicated by overlapping clinical features and frequent co-pathology that challenges the interpretation of single-protein biomarkers. We evaluated a multimodal, minimally invasive biomarker strategy integrating dermal α-synuclein and 4-repeat tau seed amplification assays (SAAs) with serum neurofilament light chain. In a prospective cohort of 166 participants (Parkinson's disease, n = 40; multiple system atrophy, n = 29; progressive supranuclear palsy (PSP), n = 77; healthy controls, n = 20) with independent external validation (63 participants), α-synuclein SAA identified synucleinopathies with high sensitivity but was positive in a subset of PSP, which is consistent with α-synuclein co-pathology. Dermal 4-repeat tau SAA identified PSP with high sensitivity and specificity. Serum neurofilament light chain distinguished multiple system atrophy from Parkinson's disease and correlated with disease severity in PSP. Integrating these complementary biomarkers improved diagnostic discrimination compared with individual markers and enabled further stratification within PSP. These findings support a multimodal biomarker approach for biologically informed diagnosis of parkinsonian syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.