ArticleCommunications biology2026
Super Enhancer RNAs Rewrite the Molecular Script of Complex Gene Regulation in the MDD Brain.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Chromatin conformational changes are key to gene regulation in the brain and have recently been shown to be regulated by super-enhancer RNAs (seRNAs). We examine the role of seRNAs in major depressive disorder (MDD) by profiling the prefrontal cortex from 25 MDD subjects and 25 matched non-psychiatric controls. Our analysis reveals 175 differentially expressed seRNAs, of which 140 are upregulated and 35 are downregulated. Our proximity mapping (±50 kb) links 94 seRNAs to nearby protein-coding genes, while long-range analysis (±500 kb) uncovered 584 seRNA-mRNA interaction pairs, most within 400 kb of genomic range. These interactions formed cis-regulatory hubs and hotspots, with notable pairs involving CEBPA, NR3C1, and DUSP1. Additionally, several genes are found to be co-regulated by distinct seRNAs. Spatial mapping confirms that many altered seRNAs are located near super-enhancer regions. Our results for the first time highlight seRNAs as key modulators of proximal and distal gene networks in MDD, offering novel insights and therapeutic avenues.
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